For embryonic stem cells to evolve into human beings, precise interplay and control within the 20,000 genes is essential. The KRAB-ZPF gene family plays an important role in this process but what exactly is its significance?
Background
Human beings and other higher mammals possess approximately 20,000 genes. These genes can be grouped in gene families which inherit different tasks. About 400 genes belong to the so-called KRAB-ZFP family. This gene family has a leading role because it can stop other genes from becoming active. They control other genes and guarantee that they are only activated at the right time in the development of mammals. They also play an important role in the development of embryonic stem cells.
But to date it remains unclear how exactly they do their work - how do they get into contact with other genes and which messengers they use? Didier Trono and colleagues from the EPF Lausanne will try to answer these questions within the next few years.
Aim
The aim is to improve our understanding of the role the important KRAB-ZPF-family plays in the development of all mammals.
Significance
This study should shed light on events which govern the earliest steps of embryonic development.
Original title: KRAB/KAP1 epigenetic regulation and pluripotent stem cell homeostasis
Grant: CHF 581‘970.-
Duration: 36 months
Project leader:
Prof. Didier Trono, Laboratoire de virologie et de génétique, EPF Lausanne